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Target
Signal transducer and activator of transcription 6
Ligand
BDBM50197554
Substrate
n/a
Meas. Tech.
ChEMBL_432301 (CHEMBL915562)
IC50
21±n/a nM
Citation
 Nagashima, S; Yokota, M; Nakai, E; Kuromitsu, S; Ohga, K; Takeuchi, M; Tsukamoto, S; Ohta, M Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg Med Chem 15:1044-55 (2006) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 6
Synonyms:
STAT6 | STAT6_HUMAN
Type:
PROTEIN
Mol. Mass.:
94129.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_881634
Residue:
847
Sequence:
MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDTVQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMDLRANPSW
  
Inhibitor
Name:
BDBM50197554
Synonyms:
2-(3-chloro-4-hydroxyphenethylamino)-4-(benzylamino)pyrimidine-5-carboxamide | 4-(benzylamino)-2-{[2-(3-chloro-4-hydroxyphenyl)ethyl]amino}pyrimidine-5-carboxamide | AS-1517499 | CHEMBL228192
Type:
Small organic molecule
Emp. Form.:
C20H20ClN5O2
Mol. Mass.:
397.858
SMILES:
NC(=O)c1cnc(NCCc2ccc(O)c(Cl)c2)nc1NCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: