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Target
Transporter
Ligand
BDBM50142839
Substrate
n/a
Meas. Tech.
ChEMBL_436642 (CHEMBL904952)
Ki
270±n/a nM
Citation
 Kim, DI; Deutsch, HM; Ye, X; Schweri, MM Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem 50:2718-31 (2007) [PubMed]  Article 
Target
Name:
Transporter
Synonyms:
Monoamine transporters; Norepininephrine & dopamine | Norepinephrine Monoamine transporters
Type:
PROTEIN
Mol. Mass.:
66787.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1463061
Residue:
597
Sequence:
MVTRTRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYVSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHLLALEIELSSLQSFVITSCPIDPLLSSFLFISCQKTLVFKKSGPAPLI
  
Inhibitor
Name:
BDBM50142839
Synonyms:
(R)-2-((R)-Methoxycarbonyl-phenyl-methyl)-piperidinium; chloride | (R)-methyl 2-phenyl-2-((R)-piperidin-2-yl)acetate hydrochloride | CHEMBL904 | DEXMETHYLPHENIDATE HYDROCHLORIDE | Focalin | Focalin xr
Type:
Small organic molecule
Emp. Form.:
C14H20NO2
Mol. Mass.:
234.3136
SMILES:
COC(=O)[C@@H]([C@H]1CCCC[NH2+]1)c1ccccc1
Structure:
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