Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50222877
Substrate
n/a
Meas. Tech.
ChEMBL_446527 (CHEMBL895698)
Ki
190±n/a nM
Citation
 Rudolph, J; Esler, WP; O'connor, S; Coish, PD; Wickens, PL; Brands, M; Bierer, DE; Bloomquist, BT; Bondar, G; Chen, L; Chuang, CY; Claus, TH; Fathi, Z; Fu, W; Khire, UR; Kristie, JA; Liu, XG; Lowe, DB; McClure, AC; Michels, M; Ortiz, AA; Ramsden, PD; Schoenleber, RW; Shelekhin, TE; Vakalopoulos, A; Tang, W; Wang, L; Yi, L; Gardell, SJ; Livingston, JN; Sweet, LJ; Bullock, WH Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity. J Med Chem 50:5202-16 (2007) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
Ghrelin receptor
Type:
PROTEIN
Mol. Mass.:
41494.35
Organism:
Ovis aries
Description:
ChEMBL_446527
Residue:
366
Sequence:
MWNATRSEELGPNLTLPDLDWDAAPDNDSLTDELPPLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWHYRPWNLGDLLCKLFQFVSESCTYASVLTITALSVERYFAICFPLRAKVVITKGRVKLVVLAIWAVAFCSAWPIFMLVGVEHENGTDPRDTNECRATEFAVRSGLLTIMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRSEVVVGASLRDQNHKQTVKMLAVVVFAFVLCWLPFHVGRYLFSKSFEPGSVEIAQISQYCNLVSFVLFYFSAAINPILYNIMSKKYRVAVFKLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50222877
Synonyms:
6-(4-chlorophenyl)-3-[(4-isopropylmorpholin-2-yl)methyl]-2-(2-methylphenyl)quinazolin-4(3H)-one | CHEMBL440952
Type:
Small organic molecule
Emp. Form.:
C29H30ClN3O2
Mol. Mass.:
488.02
SMILES:
CC(C)N1CCOC(Cn2c(nc3ccc(cc3c2=O)-c2ccc(Cl)cc2)-c2ccccc2C)C1 |w:7.7|
Structure:
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