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Target
Delta-type opioid receptor
Ligand
BDBM50027247
Substrate
n/a
Meas. Tech.
ChEMBL_446659 (CHEMBL896954)
Ki
4.8±n/a nM
Citation
 Rennison, D; Neal, AP; Cami-Kobeci, G; Aceto, MD; Martinez-Bermejo, F; Lewis, JW; Husbands, SM Cinnamoyl derivatives of 7alpha-aminomethyl-6,14-endo-ethanotetrahydrothebaine and 7alpha-aminomethyl-6,14-endo-ethanotetrahydrooripavine and related opioid ligands. J Med Chem 50:5176-82 (2007) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50027247
Synonyms:
CHEMBL2113314
Type:
Small organic molecule
Emp. Form.:
C32H34N2O4
Mol. Mass.:
510.6234
SMILES:
[H][C@]12CN(C[C@@]1([H])[C@]13C=C[C@@]2(OC)[C@]2([H])Oc4c5c(C[C@@]1([H])N(C)CC[C@@]325)ccc4O)C(=O)\C=C\c1ccc(C)cc1 |c:9,TLB:23:22:18.17.19:7|
Structure:
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