Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM50220217
Substrate
n/a
Meas. Tech.
ChEMBL_449135 (CHEMBL899400)
Ki
8200±n/a nM
Citation
 Bhattarai, BR; Shrestha, S; Ham, SW; Kim, KR; Cheon, HG; Lee, KH; Cho, H 2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity. Bioorg Med Chem Lett 17:5357-60 (2007) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM50220217
Synonyms:
CHEMBL238138 | [3-hydroxy-3',5'-bis-trifluoromethyl-5-(4-trifluoromethyl-benzyloxy)-biphenyl-4-yloxy]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C24H15F9O5
Mol. Mass.:
554.3585
SMILES:
OC(=O)COc1c(O)cc(cc1OCc1ccc(cc1)C(F)(F)F)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: