Reaction Details Report a problem with these data
Target
Trans-2-enoyl-ACP reductase II
Ligand
BDBM50216891
Substrate
n/a
Meas. Tech.
ChEMBL_450119 (CHEMBL900394)
IC50
88±n/a nM
Citation
Ozawa, T; Kitagawa, H; Yamamoto, Y; Takahata, S; Iida, M; Osaki, Y; Yamada, K Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK. Bioorg Med Chem 15:7325-36 (2007) [PubMed] Article
More Info.:
Target
Name:
Trans-2-enoyl-ACP reductase II
Synonyms:
Enoyl-ACP Reductase (FabK) | FabK | NADH-dependent, FAD-containing enoyl-ACP | trans-2-enoyl-ACP reductase II
Type:
Enzyme
Mol. Mass.:
34170.89
Organism:
Streptococcus pneumoniae
Description:
n/a
Residue:
324
Sequence:
MKTRITELLKIDYPIFQGGMAWVADGDLAGAVSKAGGLGIIGGGNAPKEVVKANIDKIKSLTDKPFGVNIMLLSPFVEDIVDLVIEEGVKVVTTGAGNPSKYMERFHEAGIIVIPVVPSVALAKRMEKIGADAVIAEGMEAGGHIGKLTTMTLVRQVATAISIPVIAAGGIADGEGAAAGFMLGAEAVQVGTRFVVAKESNAHPNYKEKILKARDIDTTISAQHFGHAVRAIKNQLTRDFELAEKDAFKQEDPDLEIFEQMGAGALAKAVVHGDVDGGSVMAGQIAGLVSKEETAEEILKDLYYGAAKKIQEEASRWTGVVRND
Inhibitor
Name:
BDBM50216891
Synonyms:
1-((4-phenyl-1H-imidazol-2-yl)methyl)-3-(6-(methylsulfonyl)benzo[d]thiazol-2-yl)urea | 1-(6-(methylsulfonyl)benzo[d]thiazol-2-yl)-3-((4-phenyl-1H-imidazol-2-yl)methyl)urea | CHEMBL245045
Type:
Small organic molecule
Emp. Form.:
C19H17N5O3S2
Mol. Mass.:
427.5
SMILES:
CS(=O)(=O)c1ccc2nc(NC(=O)NCc3nc(c[nH]3)-c3ccccc3)sc2c1