Reaction Details Report a problem with these data
Target
Trans-2-enoyl-ACP reductase II
Ligand
BDBM50219763
Substrate
n/a
Meas. Tech.
ChEMBL_450119 (CHEMBL900394)
IC50
2.4±n/a nM
Citation
 Ozawa, T; Kitagawa, H; Yamamoto, Y; Takahata, S; Iida, M; Osaki, Y; Yamada, K Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK. Bioorg Med Chem 15:7325-36 (2007) [PubMed]  Article 
Target
Name:
Trans-2-enoyl-ACP reductase II
Synonyms:
Enoyl-ACP Reductase (FabK) | FabK | NADH-dependent, FAD-containing enoyl-ACP | trans-2-enoyl-ACP reductase II
Type:
Enzyme
Mol. Mass.:
34170.89
Organism:
Streptococcus pneumoniae
Description:
n/a
Residue:
324
Sequence:
MKTRITELLKIDYPIFQGGMAWVADGDLAGAVSKAGGLGIIGGGNAPKEVVKANIDKIKSLTDKPFGVNIMLLSPFVEDIVDLVIEEGVKVVTTGAGNPSKYMERFHEAGIIVIPVVPSVALAKRMEKIGADAVIAEGMEAGGHIGKLTTMTLVRQVATAISIPVIAAGGIADGEGAAAGFMLGAEAVQVGTRFVVAKESNAHPNYKEKILKARDIDTTISAQHFGHAVRAIKNQLTRDFELAEKDAFKQEDPDLEIFEQMGAGALAKAVVHGDVDGGSVMAGQIAGLVSKEETAEEILKDLYYGAAKKIQEEASRWTGVVRND
  
Inhibitor
Name:
BDBM50219763
Synonyms:
1-((4-(4-bromophenyl)-1H-imidazol-2-yl)methyl)-3-(5-(pyridin-2-ylthio)thiazol-2-yl)urea | 1-((5-(4-bromophenyl)-1H-imidazol-2-yl)methyl)-3-(5-(pyridin-2-ylthio)thiazol-2-yl)urea | CHEMBL244805
Type:
Small organic molecule
Emp. Form.:
C19H15BrN6OS2
Mol. Mass.:
487.396
SMILES:
Brc1ccc(cc1)-c1c[nH]c(CNC(=O)Nc2ncc(Sc3ccccn3)s2)n1
Structure:
Search PDB for entries with ligand similarity: