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Target
Urokinase-type plasminogen activator
Ligand
BDBM50228417
Substrate
n/a
Meas. Tech.
ChEMBL_452505 (CHEMBL902744)
IC50
7.7±n/a nM
Citation
 Joossens, J; Ali, OM; El-Sayed, I; Surpateanu, G; Van der Veken, P; Lambeir, AM; Setyono-Han, B; Foekens, JA; Schneider, A; Schmalix, W; Haemers, A; Augustyns, K Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties. J Med Chem 50:6638-46 (2007) [PubMed]  Article 
Target
Name:
Urokinase-type plasminogen activator
Synonyms:
PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator/surface receptor
Type:
Enzyme
Mol. Mass.:
48528.62
Organism:
Homo sapiens (Human)
Description:
P00749
Residue:
431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
  
Inhibitor
Name:
BDBM50228417
Synonyms:
CHEMBL238491 | diphenyl 1-(o-toluenesulfonylamino)-2-(4-guanidinophenyl)-ethanephosphonate
Type:
Small organic molecule
Emp. Form.:
C28H29N4O5PS
Mol. Mass.:
564.592
SMILES:
[#7]\[#6](-[#7])=[#7]\c1ccc(-[#6]-[#6](-[#7]S(=O)(=O)[#6]-c2ccccc2)P(=O)([#8]-c2ccccc2)[#8]-c2ccccc2)cc1 |w:9.9|
Structure:
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