Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 2
Ligand
BDBM50203009
Substrate
n/a
Meas. Tech.
ChEMBL_454110 (CHEMBL903301)
IC50
25000±n/a nM
Citation
 McCleland, BW; Davis, RS; Palovich, MR; Widdowson, KL; Werner, ML; Burman, M; Foley, JJ; Schmidt, DB; Sarau, HM; Rogers, M; Salyers, KL; Gorycki, PD; Roethke, TJ; Stelman, GJ; Azzarano, LM; Ward, KW; Busch-Petersen, J Comparison of N,N'-diarylsquaramides and N,N'-diarylureas as antagonists of the CXCR2 chemokine receptor. Bioorg Med Chem Lett 17:1713-7 (2007) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM50203009
Synonyms:
1-(2-hydroxy-4-methylphenyl)-3-phenylurea | CHEMBL241514
Type:
Small organic molecule
Emp. Form.:
C14H14N2O2
Mol. Mass.:
242.2732
SMILES:
Cc1ccc(NC(=O)Nc2ccccc2)c(O)c1
Structure:
Search PDB for entries with ligand similarity: