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Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM50224586
Substrate
n/a
Meas. Tech.
ChEMBL_458316 (CHEMBL925647)
Ki
6290±n/a nM
Citation
 Zhao, Z; Araldi, GL; Xiao, Y; Reddy, AP; Liao, Y; Karra, S; Brugger, N; Fischer, D; Palmer, E Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists. Bioorg Med Chem Lett 17:6572-5 (2007) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_HUMAN | PGE receptor EP2 subtype | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype | Prostanoid EP2 Receptor
Type:
Enzyme
Mol. Mass.:
39775.71
Organism:
Homo sapiens (Human)
Description:
P43116
Residue:
358
Sequence:
MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
  
Inhibitor
Name:
BDBM50224586
Synonyms:
4-(2-(2-(4-(3-fluorophenyl)-3-hydroxybutyl)-5-oxopyrazolidin-1-yl)ethyl)benzoic acid | CHEMBL400446
Type:
Small organic molecule
Emp. Form.:
C22H25FN2O4
Mol. Mass.:
400.4433
SMILES:
OC(CCN1CCC(=O)N1CCc1ccc(cc1)C(O)=O)Cc1cccc(F)c1
Structure:
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