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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50219732
Substrate
n/a
Meas. Tech.
ChEMBL_459330 (CHEMBL926489)
IC50
25000±n/a nM
Citation
Hamann, M; Alonso, D; Martín-Aparicio, E; Fuertes, A; Pérez-Puerto, MJ; Castro, A; Morales, S; Navarro, ML; Del Monte-Millán, M; Medina, M; Pennaka, H; Balaiah, A; Peng, J; Cook, J; Wahyuono, S; Martínez, A Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease. J Nat Prod 70:1397-405 (2007) [PubMed] Article
More Info.:
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
Inhibitor
Name:
BDBM50219732
Synonyms:
3-[2-(Azacycloundec-6-en-1-yl)-ethyl]-5H-pyrido[4,3-b]indole | CHEMBL399493 | manzamine E
Type:
Small organic molecule
Emp. Form.:
C36H44N4O2
Mol. Mass.:
564.7602
SMILES:
O[C@@]12CC\C=C/CCCCN3CCC(C(=C1)c1nccc4c5ccccc5[nH]c14)[C@]1(C[C@@H]4CCC(=O)CCCN4[C@@H]21)C3 |w:13.12,c:4,14|