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Target
Tyrosine 3-monooxygenase
Ligand
BDBM50007425
Substrate
n/a
Meas. Tech.
ChEMBL_461134 (CHEMBL944157)
IC50
1000±n/a nM
Citation
 Zhang, A; Zhang, Y; Branfman, AR; Baldessarini, RJ; Neumeyer, JL Advances in development of dopaminergic aporphinoids. J Med Chem 50:171-81 (2007) [PubMed]  Article 
Target
Name:
Tyrosine 3-monooxygenase
Synonyms:
TH | TY3H_HUMAN | TYH | Tyrosine 3-hydroxylase | Tyrosine 3-monooxygenase
Type:
PROTEIN
Mol. Mass.:
58596.96
Organism:
Homo sapiens (Human)
Description:
ChEMBL_461134
Residue:
528
Sequence:
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTPRSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
  
Inhibitor
Name:
BDBM50007425
Synonyms:
(S) 6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol | (S)-10,11-Dihydroxy-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolinium | (S)-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol | CHEMBL330274
Type:
Small organic molecule
Emp. Form.:
C19H21NO2
Mol. Mass.:
295.3755
SMILES:
CCCN1CCc2cccc-3c2[C@@H]1Cc1ccc(O)c(O)c-31
Structure:
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