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Target
B1 bradykinin receptor
Ligand
BDBM50371329
Substrate
n/a
Meas. Tech.
ChEMBL_463209 (CHEMBL947206)
Ki
1090±n/a nM
Citation
 Wood, MR; Schirripa, KM; Kim, JJ; Kuduk, SD; Chang, RK; Di Marco, CN; DiPardo, RM; Wan, BL; Murphy, KL; Ransom, RW; Chang, RS; Holahan, MA; Cook, JJ; Lemaire, W; Mosser, SD; Bednar, RA; Tang, C; Prueksaritanont, T; Wallace, AA; Mei, Q; Yu, J; Bohn, DL; Clayton, FC; Adarayn, ED; Sitko, GR; Leonard, YM; Freidinger, RM; Pettibone, DJ; Bock, MG Alpha-hydroxy amides as a novel class of bradykinin B1 selective antagonists. Bioorg Med Chem Lett 18:716-20 (2008) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50371329
Synonyms:
CHEMBL256793
Type:
Small organic molecule
Emp. Form.:
C21H23F2NO4
Mol. Mass.:
391.4084
SMILES:
CCC(O)(CC)C(=O)NCc1ccc(cc1F)-c1cccc(F)c1C(=O)OC
Structure:
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