Reaction Details Report a problem with these data
Target
Disintegrin and metalloproteinase domain-containing protein 17
Ligand
BDBM50371338
Substrate
n/a
Meas. Tech.
ChEMBL_463233 (CHEMBL930623)
IC50
1±n/a nM
Citation
 Ott, GR; Asakawa, N; Lu, Z; Liu, RQ; Covington, MB; Vaddi, K; Qian, M; Newton, RC; Christ, DD; Traskos, JM; Decicco, CP; Duan, JJ Alpha,beta-cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE). Bioorg Med Chem Lett 18:694-9 (2008) [PubMed]  Article 
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 17
Synonyms:
A disintegrin and metalloproteinase domain 17 | ADA17_PIG | ADAM 17 | ADAM17 | Snake venom-like protease | TACE | TNF-alpha-Converting Enzyme
Type:
Metalloprotease
Mol. Mass.:
12197.99
Organism:
Sus scrofa (pig)
Description:
Partially purified TACE was obtained from porcine spleen.
Residue:
112
Sequence:
MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
  
Inhibitor
Name:
BDBM50371338
Synonyms:
CHEMBL256621
Type:
Small organic molecule
Emp. Form.:
C23H23N3O5
Mol. Mass.:
421.4458
SMILES:
Cc1cc(COc2ccc(cc2)C(=O)N[C@@H]2COC[C@@H]2C(=O)NO)c2ccccc2n1
Structure:
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