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Target
Tyrosine-protein kinase Fyn
Ligand
BDBM50372158
Substrate
n/a
Meas. Tech.
ChEMBL_464763 (CHEMBL930129)
IC50
>12500±n/a nM
Citation
 Dai, Y; Hartandi, K; Soni, NB; Pease, LJ; Reuter, DR; Olson, AM; Osterling, DJ; Doktor, SZ; Albert, DH; Bouska, JJ; Glaser, KB; Marcotte, PA; Stewart, KD; Davidsen, SK; Michaelides, MR Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors. Bioorg Med Chem Lett 18:386-90 (2008) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Fyn
Synonyms:
FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn
Type:
Enzyme
Mol. Mass.:
60762.21
Organism:
Homo sapiens (Human)
Description:
P06241
Residue:
537
Sequence:
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
  
Inhibitor
Name:
BDBM50372158
Synonyms:
CHEMBL404367
Type:
Small organic molecule
Emp. Form.:
C21H20N6O
Mol. Mass.:
372.4231
SMILES:
Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cncc3n(C)nc(N)c23)c1
Structure:
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