Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50157884
Substrate
n/a
Meas. Tech.
ChEMBL_464936 (CHEMBL946993)
IC50
3890±n/a nM
Citation
 Paris, M; Porcelloni, M; Binaschi, M; Fattori, D Histone deacetylase inhibitors: from bench to clinic. J Med Chem 51:1505-29 (2008) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50157884
Synonyms:
6-(2-Mercapto-acetylamino)-hexanoic acid phenylamide | 6-(2-mercaptoacetamido)-N-phenylhexanamide | CHEMBL178727
Type:
Small organic molecule
Emp. Form.:
C14H20N2O2S
Mol. Mass.:
280.386
SMILES:
SCC(=O)NCCCCCC(=O)Nc1ccccc1
Structure:
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