Reaction Details Report a problem with these data
Target
Transcription factor p65
Ligand
BDBM50372522
Substrate
n/a
Meas. Tech.
ChEMBL_465172 (CHEMBL945842)
IC50
1100±n/a nM
Citation
 Xie, Y; Deng, S; Thomas, CJ; Liu, Y; Zhang, YQ; Rinderspacher, A; Huang, W; Gong, G; Wyler, M; Cayanis, E; Aulner, N; Többen, U; Chung, C; Pampou, S; Southall, N; Vidovic, D; Schürer, S; Branden, L; Davis, RE; Staudt, LM; Inglese, J; Austin, CP; Landry, DW; Smith, DH; Auld, DS Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation. Bioorg Med Chem Lett 18:329-35 (2008) [PubMed]  Article 
Target
Name:
Transcription factor p65
Synonyms:
NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1
Type:
Enzyme
Mol. Mass.:
60211.92
Organism:
Homo sapiens (Human)
Description:
Q04206
Residue:
551
Sequence:
MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS
  
Inhibitor
Name:
BDBM50372522
Synonyms:
CHEMBL269941
Type:
Small organic molecule
Emp. Form.:
C17H12F3N3O4S
Mol. Mass.:
411.355
SMILES:
Cc1ccc2cccc(NS(=O)(=O)c3ccc(cc3[N+]([O-])=O)C(F)(F)F)c2n1
Structure:
Search PDB for entries with ligand similarity: