Target
Quorum-sensing transcriptional repressor QscR
Ligand
BDBM50373106
Substrate
n/a
Meas. Tech.
ChEMBL_466843 (CHEMBL925891)
IC50
200±n/a nM
Citation
 Mattmann, MEGeske, GDWorzalla, GAChandler, JRSappington, KJGreenberg, EPBlackwell, HE Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa. Bioorg Med Chem Lett 18:3072-5 (2008) [PubMed]  Article 
Target
Name:
Quorum-sensing transcriptional repressor QscR
Synonyms:
PhzR
Type:
PROTEIN
Mol. Mass.:
27251.33
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_466843
Residue:
237
Sequence:
MHDEREGYLEILSRITTEEEFFSLVLEICGNYGFEFFSFGARAPFPLTAPKYHFLSNYPGEWKSRYISEDYTSIDPIVRHGLLEYTPLIWNGEDFQENRFFWEEALHHGIRHGWSIPVRGKYGLISMLSLVRSSESIAATEILEKESFLLWITSMLQATFGDLLAPRIVPESNVRLTARETEMLKWTAVGKTYGEIGLILSIDQRTVKFHIVNAMRKLNSSNKAEATMKAYAIGLLN
  
Inhibitor
Name:
BDBM50373106
Synonyms:
CHEMBL259440
Type:
Small organic molecule
Emp. Form.:
C17H22N2O5
Mol. Mass.:
334.367
SMILES:
CC(C)(C)OC(=O)NCc1ccc(cc1)C(=O)N[C@H]1CCOC1=O
Structure:
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