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Target
Nociceptin receptor
Ligand
BDBM50239749
Substrate
n/a
Meas. Tech.
ChEMBL_467784 (CHEMBL931348)
IC50
1.2±n/a nM
Citation
 Okamoto, O; Kobayashi, K; Kawamoto, H; Ito, S; Satoh, A; Kato, T; Yamamoto, I; Mizutani, S; Hashimoto, M; Shimizu, A; Sakoh, H; Nagatomi, Y; Iwasawa, Y; Takahashi, H; Ishii, Y; Ozaki, S; Ohta, H Identification of novel benzimidazole series of potent and selective ORL1 antagonists. Bioorg Med Chem Lett 18:3278-81 (2008) [PubMed]  Article 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM50239749
Synonyms:
2-(4-(6-chloro-2-(3-methylpentan-3-ylthio)-3H-benzo[d]imidazol-5-yl)piperazin-1-yl)ethanol | 5-chloro-2-[(1-ethyl-1-methylpropyl)thio]-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1H-benzimidazole | CHEMBL263918
Type:
Small organic molecule
Emp. Form.:
C19H29ClN4OS
Mol. Mass.:
396.978
SMILES:
CCC(C)(CC)Sc1nc2cc(Cl)c(cc2[nH]1)N1CCN(CCO)CC1
Structure:
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