Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50231513
Substrate
n/a
Meas. Tech.
ChEMBL_468344 (CHEMBL931807)
EC50
1100±n/a nM
Citation
 Kasuga, J; Yamasaki, D; Ogura, K; Shimizu, M; Sato, M; Makishima, M; Doi, T; Hashimoto, Y; Miyachi, H SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail. Bioorg Med Chem Lett 18:1110-5 (2008) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50231513
Synonyms:
(+/-)-2-{3-[(4-Adamantan-1-yl-benzoylamino)-methyl]-4-methoxy-benzyl}-butyric acid | CHEMBL402161 | rac-2-{3-[(4-adamantan-1-yl-benzoylamino)-methyl]-4-methoxy-benzyl}-butyric acid
Type:
Small organic molecule
Emp. Form.:
C30H37NO4
Mol. Mass.:
475.6191
SMILES:
CCC(Cc1ccc(OC)c(CNC(=O)c2ccc(cc2)C23CC4CC(CC(C4)C2)C3)c1)C(O)=O |TLB:18:21:24.23.28:26,THB:22:23:26:30.21.29,22:21:24.23.28:26,29:21:24:28.27.26,29:27:24:30.22.21,18:21:24:28.27.26|
Structure:
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