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TargetLysophosphatidic acid receptor Edg-4
LigandBDBM50373819
Substrate/Competitorn/a
Meas. Tech.ChEMBL_468548
IC50 1700±n/a nM
Citation Beck, HPKohn, TRubenstein, SHedberg, CSchwandner, RHasslinger, KDai, KLi, CLiang, LWesche, HFrank, BAn, SWickramasinghe, DJaen, JMedina, JHungate, RShen, W Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents. Bioorg Med Chem Lett18:1037-41 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysophosphatidic acid receptor Edg-4
Name:Lysophosphatidic acid receptor Edg-4
Synonyms:LPA receptor 2 | LPA-2 | Lysophosphatidic acid receptor 2
Type:PROTEIN
Mol. Mass.:39103.44
Organism:Homo sapiens (Human)
Description:ChEMBL_1451385
Residue:351
Sequence:
MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASN
RRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVA
TLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSR
MAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLV
KTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDA
EMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50373819
NameBDBM50373819
Synonyms:CHEMBL402218
TypeSmall organic molecule
Emp. Form.C24H28FN5
Mol. Mass.405.511
SMILESCC(CN1CCN(CC1)c1ccc(F)cc1)Nc1nc(nc2ccccc12)C1CC1 |w:1.0|
Structure
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n/a