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TargetLysophosphatidic acid receptor Edg-4
LigandBDBM50373821
Substrate/Competitorn/a
Meas. Tech.ChEMBL_468543
IC50 730±n/a nM
Citation Beck, HPKohn, TRubenstein, SHedberg, CSchwandner, RHasslinger, KDai, KLi, CLiang, LWesche, HFrank, BAn, SWickramasinghe, DJaen, JMedina, JHungate, RShen, W Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents. Bioorg Med Chem Lett18:1037-41 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysophosphatidic acid receptor Edg-4
Name:Lysophosphatidic acid receptor Edg-4
Synonyms:LPA receptor 2 | LPA-2 | Lysophosphatidic acid receptor 2
Type:PROTEIN
Mol. Mass.:39103.44
Organism:Homo sapiens (Human)
Description:ChEMBL_1451385
Residue:351
Sequence:
MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASN
RRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVA
TLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSR
MAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLV
KTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDA
EMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50373821
NameBDBM50373821
Synonyms:CHEMBL401747
TypeSmall organic molecule
Emp. Form.C23H26F3N5
Mol. Mass.429.4812
SMILESC[C@@H](CN1CCN(CC1)c1ccccc1C)Nc1nc(nc2ccccc12)C(F)(F)F
Structure
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n/a