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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50373833
Substrate
n/a
Meas. Tech.
ChEMBL_468552 (CHEMBL930976)
IC50
>150000±n/a nM
Citation
 Lewis, LM; Sheffler, D; Williams, R; Bridges, TM; Kennedy, JP; Brogan, JT; Mulder, MJ; Williams, L; Nalywajko, NT; Niswender, CM; Weaver, CD; Conn, PJ; Lindsley, CW Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists. Bioorg Med Chem Lett 18:885-90 (2008) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52841.70
Organism:
RAT
Description:
Cholinergic, muscarinic M4 CHRM4 RAT::P08485
Residue:
477
Sequence:
MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50373833
Synonyms:
CHEMBL404874
Type:
Small organic molecule
Emp. Form.:
C18H28ClN3O
Mol. Mass.:
337.887
SMILES:
CCN1CCN(CC1)c1ccc(NC(=O)CC(C)(C)C)cc1Cl
Structure:
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