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Target
Segment polarity protein dishevelled homolog DVL-3
Ligand
BDBM50373851
Substrate
n/a
Meas. Tech.
ChEMBL_468589 (CHEMBL931112)
IC50
160000±n/a nM
Citation
 Mahindroo, N; Punchihewa, C; Bail, AM; Fujii, N Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity. Bioorg Med Chem Lett 18:946-9 (2008) [PubMed]  Article 
Target
Name:
Segment polarity protein dishevelled homolog DVL-3
Synonyms:
DSH homolog 3 | DVL3 | DVL3_HUMAN | Dishevelled-3 | KIAA0208
Type:
PROTEIN
Mol. Mass.:
78056.01
Organism:
Homo sapiens (Human)
Description:
ChEMBL_468589
Residue:
716
Sequence:
MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPDPAPFCADNPSELPPPMERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHATRLNGTAKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLASSLRSHHTHPSYGPPGVPPLYGPPMLMMPPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM
  
Inhibitor
Name:
BDBM50373851
Synonyms:
CHEMBL256431
Type:
Small organic molecule
Emp. Form.:
C24H28N2O3
Mol. Mass.:
392.4907
SMILES:
CCC(C)CNC(=O)c1[nH]c2cc(C)c(cc2c1CCc1ccccc1)C(O)=O |w:2.2|
Structure:
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