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TargetHistamine H3 receptor
LigandBDBM50232355
Substrate/Competitorn/a
Meas. Tech.ChEMBL_468943
Ki 0.1±n/a nM
Citation Santora, VJCovel, JAHayashi, RHofilena, BJIbarra, JBPulley, MDWeinhouse, MISengupta, DDuffield, JJSemple, GWebb, RRSage, CRen, APereira, GKnudsen, JEdwards, JESuarez, MFrazer, JThomsen, WHauser, EWhelan, KGrottick, AJ A new family of H3 receptor antagonists based on the natural product Conessine. Bioorg Med Chem Lett18:1490-4 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H3 receptor
Name:Histamine H3 receptor
Synonyms:HH3R
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:48607.98
Organism:Rattus norvegicus (rat)
Description:n/a
Residue:445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50232355
NameBDBM50232355
Synonyms:(3aR,6aR)-2-(cyclopropylmethyl)-6-(4-(2-(pyrrolidin-1-yl)ethyl)phenyl)-1,2,3,3a,4,6a-hexahydrocyclopenta[c]pyrrole | CHEMBL408934
TypeSmall organic molecule
Emp. Form.C23H32N2
Mol. Mass.336.5136
SMILESC(Cc1ccc(cc1)C1=CC[C@H]2CN(CC3CC3)C[C@@H]12)N1CCCC1 |r,t:9|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a