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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50122390
Substrate
n/a
Meas. Tech.
ChEMBL_468977 (CHEMBL952122)
IC50
0.130000±n/a nM
Citation
 Kolb, P; Huang, D; Dey, F; Caflisch, A Discovery of kinase inhibitors by high-throughput docking and scoring based on a transferable linear interaction energy model. J Med Chem 51:1179-88 (2008) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50122390
Synonyms:
5-(2-Chloro-4-fluoro-phenyl)-1-(2,6-dichloro-phenyl)-7-piperazin-1-ylmethyl-3,4-dihydro-1H-quinazolin-2-one | 5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(piperazin-1-ylmethyl)-3,4-dihydroquinazolin-2(1H)-one | CHEMBL327746
Type:
Small organic molecule
Emp. Form.:
C25H22Cl3FN4O
Mol. Mass.:
519.826
SMILES:
Fc1ccc(c(Cl)c1)-c1cc(CN2CCNCC2)cc2N(C(=O)NCc12)c1c(Cl)cccc1Cl
Structure:
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