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Target
Granzyme B
Ligand
BDBM50374383
Substrate
n/a
Meas. Tech.
ChEMBL_469245 (CHEMBL948945)
Ki
85±n/a nM
Citation
 Maryanoff, BE; Costanzo, MJ Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem 16:1562-95 (2008) [PubMed]  Article 
Target
Name:
Granzyme B
Synonyms:
CGL1 | CSPB | CTLA1 | GRAB_HUMAN | GRB | GZMB
Type:
PROTEIN
Mol. Mass.:
27735.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_469245
Residue:
247
Sequence:
MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWIKKTMKRY
  
Inhibitor
Name:
BDBM50374383
Synonyms:
CHEMBL436855
Type:
Small organic molecule
Emp. Form.:
C32H35N5O7S
Mol. Mass.:
633.715
SMILES:
CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@H]1CCc2cccc3C[C@H](N(c23)C1=O)C(=O)N[C@@H](CC(O)=O)C(=O)c1nc2ccccc2s1
Structure:
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