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Target
Synaptic vesicular amine transporter
Ligand
BDBM50374534
Substrate
n/a
Meas. Tech.
ChEMBL_469572 (CHEMBL932301)
Ki
4500±n/a nM
Citation
 Wimalasena, DS; Perera, RP; Heyen, BJ; Balasooriya, IS; Wimalasena, K Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: a structure-activity study. J Med Chem 51:760-8 (2008) [PubMed]  Article 
Target
Name:
Synaptic vesicular amine transporter
Synonyms:
Monoamine transporter | SLC18A2 | Solute carrier family 18 member 2 | VAT2 | VMAT2 | VMAT2_BOVIN | Vesicular amine transporter 2
Type:
PROTEIN
Mol. Mass.:
55749.95
Organism:
Bos taurus
Description:
ChEMBL_469572
Residue:
517
Sequence:
MALSELALLRRLQESRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIEHEKDALEIQTAKPGLTASAPGSFQNIFSYYDNSTMVTGNSTDHLQGALVHEATTQHMATNSSSASSDCPSEDKDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFTGFCIMFISTVMFAFSRTYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNAMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLRDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSHKWQLGVAFLPASVSYLIGTNVFGILAHKMGRWLCALLGMIIVGMSILCIPLAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNSSQSHPIGEDEESESD
  
Inhibitor
Name:
BDBM50374534
Synonyms:
CHEMBL270469
Type:
Small organic molecule
Emp. Form.:
C26H22N
Mol. Mass.:
348.459
SMILES:
C=C(C[n+]1ccc(cc1)-c1ccccc1)c1ccc(cc1)-c1ccccc1
Structure:
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