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Target
Gamma-aminobutyric acid receptor subunit rho-1
Ligand
BDBM24189
Substrate
n/a
Meas. Tech.
ChEMBL_469765 (CHEMBL945997)
IC50
5400±n/a nM
Citation
 Hinton, T; Chebib, M; Johnston, GA Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors. Bioorg Med Chem Lett 18:402-4 (2008) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit rho-1
Synonyms:
GABA receptor rho-1 subunit | GABA-C receptor | GABRR1 | GBRR1_HUMAN
Type:
PROTEIN
Mol. Mass.:
55892.34
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456653
Residue:
479
Sequence:
MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
  
Inhibitor
Name:
BDBM24189
Synonyms:
3-aminopropylphosphinic derivative, (R)-4 | 3-aminopropylphosphinic derivative, (S)-4 | CGP44532 | CHEMBL113304 | CHEMBL113310 | [(2S)-3-amino-2-hydroxypropyl](methyl)phosphinic acid
Type:
Small organic molecule
Emp. Form.:
C4H12NO3P
Mol. Mass.:
153.1167
SMILES:
CP(O)(O)CC(=O)CN
Structure:
Search PDB for entries with ligand similarity: