Target
MAP kinase-activated protein kinase 2
Ligand
BDBM50374681
Substrate
n/a
Meas. Tech.
ChEMBL_469831 (CHEMBL949020)
IC50
2±n/a nM
Citation
 Goldberg, DRChoi, YCogan, DCorson, MDeLeon, RGao, AGruenbaum, LHao, MHJoseph, DKashem, MAMiller, CMoss, NNetherton, MRPargellis, CPPelletier, JSellati, RSkow, DTorcellini, CTseng, YCWang, JWasti, RWerneburg, BWu, JPXiong, Z Pyrazinoindolone inhibitors of MAPKAP-K2. Bioorg Med Chem Lett 18:938-41 (2008) [PubMed]  Article 
Target
Name:
MAP kinase-activated protein kinase 2
Synonyms:
MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45579.87
Organism:
Homo sapiens (Human)
Description:
P49137
Residue:
400
Sequence:
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
  
Inhibitor
Name:
BDBM50374681
Synonyms:
CHEMBL257834
Type:
Small organic molecule
Emp. Form.:
C29H36N6O3S
Mol. Mass.:
548.7
SMILES:
CC(C)(C)CN1CCC(CC1)NC(=O)c1csc(NC(=O)c2ccc3cc4C(=O)NCC5(CCC5)n4c3c2)n1
Structure:
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