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Target
Solanesyl diphosphate synthase
Ligand
BDBM50341916
Substrate
n/a
Meas. Tech.
ChEMBL_469918 (CHEMBL939265)
IC50
252±n/a nM
Citation
 Szajnman, SH; García Liñares, GE; Li, ZH; Jiang, C; Galizzi, M; Bontempi, EJ; Ferella, M; Moreno, SN; Docampo, R; Rodriguez, JB Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. Bioorg Med Chem 16:3283-90 (2008) [PubMed]  Article 
Target
Name:
Solanesyl diphosphate synthase
Synonyms:
Farnesyl synthetase, putative | Solanesyl diphosphate synthase
Type:
PROTEIN
Mol. Mass.:
39372.51
Organism:
Trypanosoma cruzi
Description:
ChEMBL_469918
Residue:
363
Sequence:
MLKTGLCRRAAATTTITSTVPSNLLTEDGRPFAMVAREVRMMQQNMAGLVSNSNNAVLNHIAKYVFSVSGKMLRPTLVAMMAHALLPPHVSEQIRAESIGSIDDISSGAIRPFLRLGEITELLHTATLVHDDVMDNSNTRRGQPTVHCLYDTKRAVLAGDFLLARASIWIAALGHSRVVLLMSTALEDLAAGEMMQMDGCFDIESYEQKSYCKTASLIANSLASTAVLAGLPNTAYEEAAAKFGKHLGIAFQIVDDCLDITGDDKNLGKPKMADMAEGIATLPVLLAAREETRVYEAVRRRFKNPGDTEMCMEAVERHGCVAEALEHAGEHCRRGVEALHALHTSPARDCLEAAMGLILTRQV
  
Inhibitor
Name:
BDBM50341916
Synonyms:
1-[(n-oct-1-ylamino)ethyl]-1,1-bisphosphonic acid | 2-(octylamino)ethane-1,1-diyldiphosphonic acid | CHEMBL260601
Type:
Small organic molecule
Emp. Form.:
C10H25NO6P2
Mol. Mass.:
317.2561
SMILES:
CCCCCCCCNCC(P(O)(O)=O)P(O)(O)=O
Structure:
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