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Target
Calcium/calmodulin-dependent protein kinase type II subunit delta
Ligand
BDBM50374977
Substrate
n/a
Meas. Tech.
ChEMBL_470095 (CHEMBL933473)
IC50
9±n/a nM
Citation
 Mavunkel, B; Xu, YJ; Goyal, B; Lim, D; Lu, Q; Chen, Z; Wang, DX; Higaki, J; Chakraborty, I; Liclican, A; Sideris, S; Laney, M; Delling, U; Catalano, R; Higgins, LS; Wang, H; Wang, J; Feng, Y; Dugar, S; Levy, DE Pyrimidine-based inhibitors of CaMKIIdelta. Bioorg Med Chem Lett 18:2404-8 (2008) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit delta
Synonyms:
CAMK2D | CAMKD | CaM kinase II | CaM kinase II delta | CaMK-II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaMKII subunit delta) | KCC2D_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
56419.78
Organism:
Homo sapiens (Human)
Description:
Q13557
Residue:
499
Sequence:
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI
  
Inhibitor
Name:
BDBM50374977
Synonyms:
CHEMBL270849
Type:
Small organic molecule
Emp. Form.:
C20H20ClN5
Mol. Mass.:
365.859
SMILES:
Clc1cccc(Nc2nccc(n2)-c2cccc(c2)N2CCNCC2)c1
Structure:
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