Reaction Details Report a problem with these data
Target
Methionine aminopeptidase 1
Ligand
BDBM50375166
Substrate
n/a
Meas. Tech.
ChEMBL_470290 (CHEMBL951176)
Ki
9000±n/a nM
Citation
 Haldar, MK; Scott, MD; Sule, N; Srivastava, DK; Mallik, S Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors. Bioorg Med Chem Lett 18:2373-6 (2008) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 1
Synonyms:
Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1
Type:
Enzyme
Mol. Mass.:
43220.79
Organism:
Homo sapiens (Human)
Description:
MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:
386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF
  
Inhibitor
Name:
BDBM50375166
Synonyms:
CHEMBL270142
Type:
Small organic molecule
Emp. Form.:
C13H10N2O3
Mol. Mass.:
242.2301
SMILES:
O=[#6]-1-[#7]-[#6](=O)\[#6](=[#6]\[#6]=[#6]\c2ccccc2)-[#6](=O)-[#7]-1
Structure:
Search PDB for entries with ligand similarity: