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Target
DNA polymerase kappa
Ligand
BDBM50375300
Substrate
n/a
Meas. Tech.
ChEMBL_470724 (CHEMBL934564)
IC50
86500±n/a nM
Citation
 Naganuma, M; Nishida, M; Kuramochi, K; Sugawara, F; Yoshida, H; Mizushina, Y 1-deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae. Bioorg Med Chem 16:2939-44 (2008) [PubMed]  Article 
Target
Name:
DNA polymerase kappa
Synonyms:
DINB1 | POLK | POLK_HUMAN
Type:
PROTEIN
Mol. Mass.:
98825.18
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1297316
Residue:
870
Sequence:
MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIKMGSSVENDNPGKEVNKLSEHERSISPLLFEESPSDVQPPGDPFQVNFEEQNNPQILQNSVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDADFPHPLRLRLMGVRISSFPNEEDRKHQQRSIIGFLQAGNQALSATECTLEKTDKDKFVKPLEMSHKKSFFDKKRSERKWSHQDTFKCEAVNKQSFQTSQPFQVLKKKMNENLEISENSDDCQILTCPVCFRAQGCISLEALNKHVDECLDGPSISENFKMFSCSHVSATKVNKKENVPASSLCEKQDYEAHPKIKEISSVDCIALVDTIDNSSKAESIDALSNKHSKEECSSLPSKSFNIEHCHQNSSSTVSLENEDVGSFRQEYRQPYLCEVKTGQALVCPVCNVEQKTSDLTLFNVHVDVCLNKSFIQELRKDKFNPVNQPKESSRSTGSSSGVQKAVTRTKRPGLMTKYSTSKKIKPNNPKHTLDIFFK
  
Inhibitor
Name:
BDBM50375300
Synonyms:
TALAROFLAVONE
Type:
Small organic molecule
Emp. Form.:
C14H12O6
Mol. Mass.:
276.2415
SMILES:
COc1cc2c(C(=O)OC22C(C)CC(=O)C2=O)c(O)c1
Structure:
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