Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50375728
Substrate
n/a
Meas. Tech.
ChEMBL_473977 (CHEMBL933958)
IC50
11±n/a nM
Citation
 Moree, WJ; Kataoka, K; Ramirez-Weinhouse, MM; Shiota, T; Imai, M; Tsutsumi, T; Sudo, M; Endo, N; Muroga, Y; Hada, T; Fanning, D; Saunders, J; Kato, Y; Myers, PL; Tarby, CM Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series. Bioorg Med Chem Lett 18:1869-73 (2008) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50375728
Synonyms:
CHEMBL257062
Type:
Small organic molecule
Emp. Form.:
C21H23ClF3N5O2
Mol. Mass.:
469.888
SMILES:
Nc1cc(CN2CC[C@H](C2)NC(=O)CNC(=O)c2cc(ccc2N)C(F)(F)F)ccc1Cl
Structure:
Search PDB for entries with ligand similarity: