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Target
Geranylgeranyl pyrophosphate synthase BTS1
Ligand
BDBM25279
Substrate
n/a
Meas. Tech.
ChEMBL_474165 (CHEMBL938423)
IC50
70±n/a nM
Citation
 Guo, RT; Cao, R; Liang, PH; Ko, TP; Chang, TH; Hudock, MP; Jeng, WY; Chen, CK; Zhang, Y; Song, Y; Kuo, CJ; Yin, F; Oldfield, E; Wang, AH Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A 104:10022-7 (2007) [PubMed]  Article 
Target
Name:
Geranylgeranyl pyrophosphate synthase BTS1
Synonyms:
BTS1 | GGPPS_YEAST | Geranylgeranyl diphosphate synthase (GGPPS) | Geranylgeranyl pyrophosphate synthase
Type:
Protein
Mol. Mass.:
38647.44
Organism:
Saccharomyces cerevisiae (Yeast)
Description:
n/a
Residue:
335
Sequence:
MEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSSHHGHSLVPFINLLGIIYQIRDDYLNLKDFQMSSEKGFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKNDNENKYLPDLASHSDTATNLHDELLYIIDHLSEL
  
Inhibitor
Name:
BDBM25279
Synonyms:
BPH-608 | bisphosphonate, 31 | {1-hydroxy-2-[3-(3-phenylphenyl)phenyl]-1-phosphonoethyl}phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C20H20O7P2
Mol. Mass.:
434.3161
SMILES:
OC(Cc1cccc(c1)-c1cccc(c1)-c1ccccc1)(P(O)(O)=O)P(O)(O)=O
Structure:
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