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TargetGeranylgeranyl diphosphate synthase (GGPPS)
LigandBDBM25288
Substrate/Competitorn/a
Meas. Tech.ChEMBL_474165
IC50 280±n/a nM
Citation Guo, RTCao, RLiang, PHKo, TPChang, THHudock, MPJeng, WYChen, CKZhang, YSong, YKuo, CJYin, FOldfield, EWang, AH Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci USA104:10022-7 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Geranylgeranyl diphosphate synthase (GGPPS)
Name:Geranylgeranyl diphosphate synthase (GGPPS)
Synonyms:Geranylgeranyl pyrophosphate synthase
Type:Protein
Mol. Mass.:38647.44
Organism:Saccharomyces cerevisiae (Yeast)
Description:n/a
Residue:335
Sequence:
MEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIV
SQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTK
EPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRL
MEALSPSSHHGHSLVPFINLLGIIYQIRDDYLNLKDFQMSSEKGFAEDITEGKLSFPIVH
ALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIK
NDNENKYLPDLASHSDTATNLHDELLYIIDHLSEL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM25288
NameBDBM25288
Synonyms:BPH-629 | [1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{2,7}]trideca-1(13),2,4,6,9,11-hexaen-6-yl}phenyl)-1-phosphonoethyl]phosphonic acid | bisphosphonate, 8
TypeSmall organic molecule
Emp. Form.C20H18O8P2
Mol. Mass.448.2996
SMILESOC(Cc1cccc(c1)-c1cccc2c1oc1ccccc21)(P(O)(O)=O)P(O)(O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a