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TargetGeranylgeranyl diphosphate synthase (GGPPS)
LigandBDBM25279
Substrate/Competitorn/a
Meas. Tech.ChEMBL_474166
Ki 30±n/a nM
Citation Guo, RTCao, RLiang, PHKo, TPChang, THHudock, MPJeng, WYChen, CKZhang, YSong, YKuo, CJYin, FOldfield, EWang, AH Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci USA104:10022-7 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Geranylgeranyl diphosphate synthase (GGPPS)
Name:Geranylgeranyl diphosphate synthase (GGPPS)
Synonyms:Geranylgeranyl pyrophosphate synthase
Type:Protein
Mol. Mass.:38647.44
Organism:Saccharomyces cerevisiae (Yeast)
Description:n/a
Residue:335
Sequence:
MEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIV
SQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTK
EPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRL
MEALSPSSHHGHSLVPFINLLGIIYQIRDDYLNLKDFQMSSEKGFAEDITEGKLSFPIVH
ALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIK
NDNENKYLPDLASHSDTATNLHDELLYIIDHLSEL
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  Blast E-value cutoff:
BDBM25279
NameBDBM25279
Synonyms:BPH-608 | bisphosphonate, 31 | {1-hydroxy-2-[3-(3-phenylphenyl)phenyl]-1-phosphonoethyl}phosphonic acid
TypeSmall organic molecule
Emp. Form.C20H20O7P2
Mol. Mass.434.3161
SMILESOC(Cc1cccc(c1)-c1cccc(c1)-c1ccccc1)(P(O)(O)=O)P(O)(O)=O
Structure
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n/a