Target
Geranylgeranyl pyrophosphate synthase BTS1
Ligand
BDBM25288
Substrate
n/a
Meas. Tech.
ChEMBL_474166 (CHEMBL938424)
Ki
110±n/a nM
Citation
 Guo, RTCao, RLiang, PHKo, TPChang, THHudock, MPJeng, WYChen, CKZhang, YSong, YKuo, CJYin, FOldfield, EWang, AH Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A 104:10022-7 (2007) [PubMed]  Article 
Target
Name:
Geranylgeranyl pyrophosphate synthase BTS1
Synonyms:
BTS1 | GGPPS_YEAST | Geranylgeranyl diphosphate synthase (GGPPS) | Geranylgeranyl pyrophosphate synthase
Type:
Protein
Mol. Mass.:
38647.44
Organism:
Saccharomyces cerevisiae (Yeast)
Description:
n/a
Residue:
335
Sequence:
MEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSSHHGHSLVPFINLLGIIYQIRDDYLNLKDFQMSSEKGFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKNDNENKYLPDLASHSDTATNLHDELLYIIDHLSEL
  
Inhibitor
Name:
BDBM25288
Synonyms:
BPH-629 | [1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{2,7}]trideca-1(13),2,4,6,9,11-hexaen-6-yl}phenyl)-1-phosphonoethyl]phosphonic acid | bisphosphonate, 8
Type:
Small organic molecule
Emp. Form.:
C20H18O8P2
Mol. Mass.:
448.2996
SMILES:
OC(Cc1cccc(c1)-c1cccc2c1oc1ccccc21)(P(O)(O)=O)P(O)(O)=O
Structure:
Search PDB for entries with ligand similarity: