Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCAAX prenyl protease 1 homolog
LigandBDBM578
Substrate/Competitorn/a
Meas. Tech.ChEMBL_476919
IC50 18400±n/a nM
Citation Coffinier, CHudon, SEFarber, EAChang, SYHrycyna, CAYoung, SGFong, LG HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Proc Natl Acad Sci USA104:13432-7 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
CAAX prenyl protease 1 homolog
Name:CAAX prenyl protease 1 homolog
Synonyms:FACE-1 | Farnesylated proteins-converting enzyme 1 | Prenyl protein-specific endoprotease 1 | Zinc metalloproteinase Ste24 homolog
Type:PROTEIN
Mol. Mass.:54735.85
Organism:Mus musculus
Description:ChEMBL_476919
Residue:475
Sequence:
MGMWASVDAMWDFPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTTRVPAELEQIMD
SDTFEKSRLYQLDKSTFSFWSGLYSEVEGTFILLFGGIPYLWRLSGQFCSSAGFGPEYEI
IQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNHQTLEFFMKDAIKKFIVTQCILLP
VSALLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDKFTPLPEGKLKQEIEV
MAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDTLLEEYSVPNKDNQEESGM
EARNEGEGDSEEVKAKVKNKKQGCKNEEVLAVLGHELGHWKLGHTVKNIIISQMNSFLCF
FLFAVLIGRRELFAAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRRFEFQADA
FAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSTWHYSHPPLLERLQALKNAKQD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM578
n/a
NameBDBM578
Synonyms:(2S)-N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide | ABT-378 | Aluviran | CHEMBL729 | LPV | Lopinavir
TypeSmall organic molecule
Emp. Form.n/a
Mol. Mass.n/a
SMILESn/a
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: