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Target
Growth hormone-releasing hormone receptor
Ligand
BDBM36351
Substrate
n/a
Meas. Tech.
ChEMBL_477144 (CHEMBL921755)
IC50
0.14±n/a nM
Citation
 Buchholz, S; Schally, AV; Engel, JB; Hohla, F; Heinrich, E; Koester, F; Varga, JL; Halmos, G Potentiation of mammary cancer inhibition by combination of antagonists of growth hormone-releasing hormone with docetaxel. Proc Natl Acad Sci U S A 104:1943-6 (2007) [PubMed]  Article 
Target
Name:
Growth hormone-releasing hormone receptor
Synonyms:
GHRH receptor | GHRHR | GHRHR_HUMAN | GRF receptor | GRFR
Type:
PROTEIN
Mol. Mass.:
47403.55
Organism:
Homo sapiens (Human)
Description:
ChEMBL_477144
Residue:
423
Sequence:
MDRRMWGAHVFCVLSPLPTVLGHMHPECDFITQLREDESACLQAAEEMPNTTLGCPATWDGLLCWPTAGSGEWVTLPCPDFFSHFSSESGAVKRDCTITGWSEPFPPYPVACPVPLELLAEEESYFSTVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHTQLFTTFILKAGAVFLKDAALFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTSPSSRRAFWWLVLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGVNFGLFLNIIRILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLGIRLPLELGLGSFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRAKWTTPSRSAAKVLTSMC
  
Inhibitor
Name:
BDBM36351
Synonyms:
CID148124 | Docetaxel
Type:
Small organic molecule
Emp. Form.:
C43H53NO14
Mol. Mass.:
807.8792
SMILES:
[H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C(C)=C([C@@H](O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C |t:39|
Structure:
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