Reaction Details Report a problem with these data
Target
Cholesteryl ester transfer protein
Ligand
BDBM50238420
Substrate
n/a
Meas. Tech.
ChEMBL_477678 (CHEMBL924744)
IC50
21000±n/a nM
Citation
 Harikrishnan, LS; Kamau, MG; Herpin, TF; Morton, GC; Liu, Y; Cooper, CB; Salvati, ME; Qiao, JX; Wang, TC; Adam, LP; Taylor, DS; Chen, AY; Yin, X; Seethala, R; Peterson, TL; Nirschl, DS; Miller, AV; Weigelt, CA; Appiah, KK; O'Connell, JC; Michael Lawrence, R 2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: optimization via array synthesis. Bioorg Med Chem Lett 18:2640-4 (2008) [PubMed]  Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50238420
Synonyms:
CHEMBL261275 | N-(4-(5-chlorobenzo[d]oxazol-2-yl)phenyl)-2-(o-tolyloxy)acetamide
Type:
Small organic molecule
Emp. Form.:
C22H17ClN2O3
Mol. Mass.:
392.835
SMILES:
Cc1ccccc1OCC(=O)Nc1ccc(cc1)-c1nc2cc(Cl)ccc2o1
Structure:
Search PDB for entries with ligand similarity: