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Target
Type-1 angiotensin II receptor A
Ligand
BDBM50145979
Substrate
n/a
Meas. Tech.
ChEMBL_478822 (CHEMBL925709)
IC50
6.9±n/a nM
Citation
 Cappelli, A; Nannicini, C; Gallelli, A; Giuliani, G; Valenti, S; Mohr, Gl; Anzini, M; Mennuni, L; Ferrari, F; Caselli, G; Giordani, A; Peris, W; Makovec, F; Giorgi, G; Vomero, S Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems. J Med Chem 51:2137-46 (2008) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor A
Synonyms:
AGTRA_RAT | ANGIOTENSIN AT1 | Agtr1 | Agtr1a | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | At1a | Type-1A angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40910.53
Organism:
RAT
Description:
ANGIOTENSIN AT1 AGTR1 RAT::P25095
Residue:
359
Sequence:
MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVCAFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
  
Inhibitor
Name:
BDBM50145979
Synonyms:
4-(4-((2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)-3-(2H-tetrazol-5-yl)quinoline | 4-[4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenyl]-3-(2H-tetrazol-5-yl)-quinoline | CHEMBL86247
Type:
Small organic molecule
Emp. Form.:
C27H24N8
Mol. Mass.:
460.5331
SMILES:
CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1c(cnc2ccccc12)-c1nnn[nH]1
Structure:
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