Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM50216550
Substrate
n/a
Meas. Tech.
ChEMBL_479051 (CHEMBL921658)
IC50
4200±n/a nM
Citation
 Richman, JG; Kanemitsu-Parks, M; Gaidarov, I; Cameron, JS; Griffin, P; Zheng, H; Guerra, NC; Cham, L; Maciejewski-Lenoir, D; Behan, DP; Boatman, D; Chen, R; Skinner, P; Ornelas, P; Waters, MG; Wright, SD; Semple, G; Connolly, DT Nicotinic acid receptor agonists differentially activate downstream effectors. J Biol Chem 282:18028-36 (2007) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41868.22
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:
363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
  
Inhibitor
Name:
BDBM50216550
Synonyms:
3-(3-chlorobenzyl)-1H-pyrazole-5-carboxylic acid | 5-(3-Chloro-benzyl)-1H-pyrazole-3-carboxylic acid | 5-meta-chlorobenzyl-3-carboxyl-pyrazole | CHEMBL394441
Type:
Small organic molecule
Emp. Form.:
C11H9ClN2O2
Mol. Mass.:
236.654
SMILES:
OC(=O)c1cc(Cc2cccc(Cl)c2)[nH]n1
Structure:
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