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Target
Protein kinase C theta type
Ligand
BDBM50239328
Substrate
n/a
Meas. Tech.
ChEMBL_480051 (CHEMBL927990)
IC50
1300±n/a nM
Citation
 Boschelli, DH; Wu, B; Barrios Sosa, AC; Chen, J; Asselin, M; Cole, DC; Lee, J; Yang, X; Chaudhary, D Synthesis and PKCtheta inhibitory activity of a series of 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles. Bioorg Med Chem Lett 18:2850-3 (2008) [PubMed]  Article 
Target
Name:
Protein kinase C theta type
Synonyms:
KPCT_MOUSE | Pkcq | Prkcq | nPKC-theta
Type:
PROTEIN
Mol. Mass.:
81587.36
Organism:
Mus musculus
Description:
ChEMBL_480051
Residue:
707
Sequence:
MSPFLRIGLSNFDCGTCQACQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGRTEIWLELKPQGRMLMNARYFLEMSDTKDMSEFENEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARSLRDSEHIFREGPVEIGLPCSTKNETRPPCVPTPGKREPQGISWDSPLDGSNKSAGPPEPEVSMRRTSLQLKLKIDDFILHKMLGKGSFGKVFLAEFKRTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEVILGLQFLHSKGIVYRDLKLDNILLDRDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLVYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEREAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPYDCSNFDKEFLSEKPRLSFADRALINSMDQNMFSNFSFINPGMETLICS
  
Inhibitor
Name:
BDBM50239328
Synonyms:
2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | CHEMBL402818
Type:
Small organic molecule
Emp. Form.:
C26H23N5S
Mol. Mass.:
437.559
SMILES:
CN(C)Cc1cccc(c1)-c1cc2c(Nc3ccc4[nH]ccc4c3C)c(cnc2s1)C#N
Structure:
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