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Target
IAG-nucleoside hydrolase
Ligand
BDBM50260490
Substrate
n/a
Meas. Tech.
ChEMBL_531315 (CHEMBL989727)
Ki
18000±n/a nM
Citation
 Goeminne, A; McNaughton, M; Bal, G; Surpateanu, G; Van Der Veken, P; De Prol, S; Versées, W; Steyaert, J; Haemers, A; Augustyns, K Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors. Eur J Med Chem 43:315-26 (2008) [PubMed]  Article 
Target
Name:
IAG-nucleoside hydrolase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
36316.77
Organism:
Trypanosoma vivax
Description:
ChEMBL_531315
Residue:
327
Sequence:
MAKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMCTHCELLRDGDGYYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAEKYPLTFVARNPEAEFFLDMLLRSARAC
  
Inhibitor
Name:
BDBM50260490
Synonyms:
(1S )-1,4-Dideoxy-1-(2-guanidinoethyl)-1,4-imino-D-ribitol | CHEMBL486805
Type:
Small organic molecule
Emp. Form.:
C8H18N4O3
Mol. Mass.:
218.2535
SMILES:
[#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6@@H]-1-[#7]-[#6@H](-[#6]-[#8])-[#6@@H](-[#8])-[#6@H]-1-[#8] |r|
Structure:
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