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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50260904
Substrate
n/a
Meas. Tech.
ChEMBL_556593 (CHEMBL958092)
IC50
0.23±n/a nM
Citation
 Jin, C; Navarro, HA; Carroll, FI Synthesis and receptor binding properties of 2beta-alkynyl and 2beta-(1,2,3-triazol)substituted 3beta-(substituted phenyl)tropane derivatives. Bioorg Med Chem 16:5529-35 (2008) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3
Type:
Multi-pass membrane protein
Mol. Mass.:
68497.11
Organism:
Homo sapiens (Human)
Description:
Q01959
Residue:
620
Sequence:
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
  
Inhibitor
Name:
BDBM50260904
Synonyms:
(1R,2R,3S,5S)-2-(2,2-dibromovinyl)-8-methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane hydrochloride | CHEMBL495464
Type:
Small organic molecule
Emp. Form.:
C17H21Br2N
Mol. Mass.:
399.163
SMILES:
[#6]-[#7]-1-[#6@H]-2-[#6]-[#6]-[#6@@H]-1-[#6@@H](\[#6]=[#6](/Br)Br)-[#6@H](-[#6]-2)-c1ccc(-[#6])cc1 |r,TLB:0:1:4.3:6.11.12,7:6:4.3:1,THB:13:11:4.3:1|
Structure:
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