Reaction Details Report a problem with these data
Target
Cathepsin G
Ligand
BDBM50269860
Substrate
n/a
Meas. Tech.
ChEMBL_508158 (CHEMBL1008216)
IC50
>50000±n/a nM
Citation
 Méthot, N; Rubin, J; Guay, D; Beaulieu, C; Ethier, D; Reddy, TJ; Riendeau, D; Percival, MD Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem 282:20836-46 (2007) [PubMed]  Article 
Target
Name:
Cathepsin G
Synonyms:
CATG_MOUSE | Ctsg
Type:
PROTEIN
Mol. Mass.:
29115.44
Organism:
Mus musculus
Description:
ChEMBL_508158
Residue:
261
Sequence:
MQPLLLLLTFILLQGDEAGKIIGGREARPHSYPYMAFLLIQSPEGLSACGGFLVREDFVLTAAHCLGSSINVTLGAHNIQMRERTQQLITVLRAIRHPDYNPQNIRNDIMLLQLRRRARRSGSVKPVALPQASKKLQPGDLCTVAGWGRVSQSRGTNVLQEVQLRVQMDQMCANRFQFYNSQTQICVGNPRERKSAFRGDSGGPLVCSNVAQGIVSYGSNNGNPPAVFTKIQSFMPWIKRTMRRFAPRYQRPANSLSQAQT
  
Inhibitor
Name:
BDBM50269860
Synonyms:
CHEMBL477531 | N-(cyanomethyl)-3-(3,5-dimethylphenyl)-2-(2,2-diphenylacetamido)propanamide
Type:
Small organic molecule
Emp. Form.:
C27H27N3O2
Mol. Mass.:
425.5222
SMILES:
Cc1cc(C)cc(CC(NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCC#N)c1
Structure:
Search PDB for entries with ligand similarity: