Target
Excitatory amino acid transporter 1
Ligand
BDBM50252047
Substrate
n/a
Meas. Tech.
ChEMBL_487931 (CHEMBL1016585)
IC50
>3000000±n/a nM
Citation
 Sagot, EJensen, AAPickering, DSPu, XUmberti, MStensbøl, TBNielsen, BAssaf, ZAboab, BBolte, JGefflaut, TBunch, L Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human excitatory amino acid transporter subtype 2. J Med Chem 51:4085-92 (2008) [PubMed]  Article 
Target
Name:
Excitatory amino acid transporter 1
Synonyms:
EAA1_HUMAN | EAAT1 | Excitatory Amino Acid EAAT1 | GLAST | GLAST1 | SLC1A3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
59577.19
Organism:
Homo sapiens (Human)
Description:
Excitatory Amino Acid EAAT1 0 HUMAN::P43003
Residue:
542
Sequence:
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVGTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPPNLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSETKM
  
Inhibitor
Name:
BDBM50252047
Synonyms:
(2S,4S)-4-(2-Hydroxy-2-oxoethyl)glutamic Acid | (2S,4S)-4-aminobutane-1,2,4-tricarboxylic acid | CHEMBL479797
Type:
Small organic molecule
Emp. Form.:
C7H11NO6
Mol. Mass.:
205.1653
SMILES:
N[C@@H](C[C@@H](CC(O)=O)C(O)=O)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: