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Target
Glycogen debranching enzyme
Ligand
BDBM50182801
Substrate
n/a
Meas. Tech.
ChEMBL_490834 (CHEMBL993573)
IC50
480000±n/a nM
Citation
 Kuriyama, C; Kamiyama, O; Ikeda, K; Sanae, F; Kato, A; Adachi, I; Imahori, T; Takahata, H; Okamoto, T; Asano, N In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg Med Chem 16:7330-6 (2008) [PubMed]  Article 
Target
Name:
Glycogen debranching enzyme
Synonyms:
AGL | GDE_RABIT
Type:
PROTEIN
Mol. Mass.:
177662.68
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_490834
Residue:
1555
Sequence:
MGNSFDFGVLLILLKYFKSSRSQNGHSKQIRILLLNEMEKLEKTLFRLEQGFELQFRLGPTLQGKPVTVFTNYPFPGETFNREKFRSLEWENPTEREDDSDKYCKLNLQQSGSFQYYFLQGNEKSGGGYIVVDPILRVGADNHMLHLDCVTLQTFLAKCLGPFDEWESRLRVAKESGYNMIHFTPLQTLGLSRSCYSLADQLELNPDFSRPHKKYTWSDVGQLVEKLKREWNVLCITDVVYNHTAANSKWIQEHPECAYNLVNSPHLKPAWVLDRALWHFSCDVAEGKYKNRGVPALIENDHHLNCIRKVIWEDIFPKLHLWEFFQVDVYKAVEKFRGLLTQETWRVIKSDPKQHLKIIQDPEYRRFGCTVDMNIALATFIPHDNGPAAIEECCNWFRKRIEELNSEKHQLMNYHQEQAVNCLLGNVFYERLAGHGPKLGPVTRKYPLVTRYFTFPFEEMPVSTEETMIHLPNKACFFMAHNGWVMGDDPLRNFAEPGSDVYLRRELICWGDSVKLRYGTKPEDCPYLWAHMRKYTEIIATYFQGVRLDNCHSTPLHVAEYMLDAARKLQPNLYVVAELFTGSEDLDNIFVTRLGISSLIREAMSAYNSHEEGRLVYRYGGEPVGSFVQPCLRPLMPAIAHALFMDITHDNECPIVHRSVYDALPSTTIVSMACCASGSTRGYDELVPHQISVVSEERFYTKWNPEALPSNAGEVNFQSGIIAARCAINKLHQELGAKGFIQVYVDQVDEDIVAVTRHSPSIHQSFVAVSRTAFRNPKTSFYSKDVPQMCIPGKIEEVVLEARTIERNISPYRKDENSINGMPNITVEIREHIQLNESRIVKQAGVTTKGPNEYIQEIEFENLSPGSVIIFRVSLDPHAQVAVGILRNHLTQFSAHFKAGSLAVDNSDPILKIPFASIASKLTLAEINQILYRCESEEQEDGGGCYDIPNWSSLKYAGLQGLMSVLAEIRPKNDLGHPFCDNLRSGDWMIDYVSGRLISRSGTIAEVGKWLQAMFFYLKQIPRYLIPCYFDAILIGAYTTLLDIAWKQMSSFVQTGSTFVKHLSLGSVQMCGVGKFPSLPLLSPSLTDVPYRLNEITKEKEQCCVSLAAGLPHFSSGIFRCWGRDTFIALRGLLLITGRYLEARNIILAFAGTLRHGLIPNLLGEGTYARYNCRDAVWWWLQCIQDYCKMVPNGLDILKCPVSRMYPTDDSAPLPAGTLDQPLFDVIQEAMQRHMQGIQFRERNAGPQIDRNMKDEGFTVIAGVNEETGFVYGGNRFNCGTWMDKMGESDRARNRGIPATPRDGSAVEIVGLCKSTVRWLLELSKKNIFPYHEVRVKRHGKVVTVSYEEWNRKIQDNFEKRFHVSEDPSASNEEHPNLVHKRGIYKDSYGASSPWCDYQLRPNFTIAMVVAPELFTAEKAWKALEIAEKKLLGPLGMKTLDPDDMVYCGIYDNALDNDNYNLAKGFNYHQGPEWLWPVGYFLRAKLYFSKLMDRETNARTIFLVKNVLSRHYVHLERSPWKGLPELTNENGQYCPFSCETQAWSIATILETLYDL
  
Inhibitor
Name:
BDBM50182801
Synonyms:
(3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8 | (3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol | 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE | AFEGOSTAT TARTRATE | CHEMBL206468 | D-Isofagomine | US10081601, Example 1.1 | US9796680, Example Table2.1 | isofagomine
Type:
Small organic molecule
Emp. Form.:
C6H13NO3
Mol. Mass.:
147.1723
SMILES:
OC[C@H]1CNC[C@@H](O)[C@@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: